I'm in your situation right now. I had a sleepover with my best friend (who just got back from Australia), and I noticed so many things were different. We're still friends, and I think we have the connection that we'll always be friends, but I've come to the realisation that people move on. Her stories were full of her boyfriend, and my stories are full of all the awesome people I've met since going to university.
I saw my ex boyfriend the other night, and I was able to carry on a fairly hilarious convo with him, but our friendship's changed too. We talk about things now that two months ago we wouldn't have dreamed of talking about with each other.
My relationship with my parents is different too. My dad and I have only fought a bit hehe, so that's good. They've given me more freedom now; instead of saying "you can or can't do this", they say "you can if you want to, just let us know if you're going to be late"
My relationship with my sister? Wow, we talk about everything under the sun now *grins*
Things have changed, and as the holidays draw slowly to a close, I find myself looking forward to the new semester, and all the cool people I'm going to meet in the next three months.
My best friend will always be a part of my life, and my family will always be the ones I turn to when I'm homesick or depressed, but life moves on, and I've learned so much from being on my own.
*hugs* if you want someone to talk to, feel free to email me