Not A Poet
Most scientific "discoveries" are achieved because something occurred which could not be explained with the then current scientific theories. That prompts scientists to experiment, searching for the underlying explanation. New or extended theories are postulated then experiments are undertaken trying to determine whether those new theories can be disproven. If they prove to be incompatible with observed results then new postulates are formed and the process begins again.
If, however, scientists cannot devise experiments which disprove the theory then it is accepted as the "current fact." This, of course, does not mean it is really a fact, only that it cannot be disproved with currently available technology. By now, I suspect most, if not all, scientists accept the premise that current science is just theories and that eventually exceptions will be found for every rule. These exceptions will then lead to other new or expanded theories which will lead to new experiments to test their plausibility.
The Greeks had no way to see the need for atomic theory. There was nothing in their knowledge based which could not be explained without it. Similarly, 100 years or so ago, there was no evidence that something smaller than the atom was indicated. Then I think it was actually after WWII that experiments indicated Protons, neutrons and electrons had to be made from smaller bits, so quarks were postulated. Subatomic physics has moved on beyond that now but the subject becomes pretty mind-boggling.
I think the never-ending nature of scientific discovery and advancement may be apparent from this discussion. I don't believe we will ever know the true nature of the universe or the physical makeup of matter or atoms or anything else, when broken to its smallest possible building blocks. But I also don't believe that such knowledge is essential. It would be interesting to know but surely not necessary.
It is our nature, however, to be inquisitive. I feel confident that we will continue to press for more knowledge and understanding of our environment (in the overall sense) even though we understand that we will probably never know everything.
Well, I guess I got off the subject a bit there but that's my $0.02 worth.
Imagination is more important than knowledge