Head to trendmicro's free download section and get cwshredder. Very effective tool for getting rid of coolweb crap and is a stand alone prog (doesn't install anything). Do a google search on spywareblaster and while there pick up spywareguard. Blaster alerts you when a Browser Helper Object (BHO) has changed and gives you a choice on what to do, while Guard loads up a ban list for both IE and Firefox. Get Adaware and Spybot S&D as they compliment each other. I would also recommend AVG Anti-Virus (all these progs are freebies). Spybot has a lot of cool features under Advanced Mode, such as your startup list (without requiring the normal msconfig reboot) and you can lock your start page and control panel easily. Before doing so, run Adaware, go into options, and change the startpage to something innocuous, such as yahoo or piptalk (shameless plug for this wonderful site). Update all the progs then disconnect from the internet completely by either physically unhooking the cable from your comp, or using a feature such as the one in ZoneAlarm to lock down all incoming and outgoing transmissions. Then run your scans and git rid of all those varmits.
Here's what I personally use, and have for about 5 years: AVG, ZoneAlarm, Spywareblaster, Spywareguard, Spybot, Adaware, and CWShredder. These are the same progs I load on other comps for deinfestations and are all free.